PROTEIN FOLDING CENTER 2ND ANNUAL RETREAT
MAY 27 - MAY 29, 2007
Name Titles Presentation sequence Allocated time(mins)
Day 1 Sunday, May 27, 2007 (2:00- 6:30 PM) 
Clark Center, http://www.stanford.edu/hpcgi/map/index.pl?q=clark+center
Chair - Sunday 2 - 6:30 pm Tanja Kortemme and Wah Chiu  
Frydman, Judith 1 5
Douglas, Nick Lid Closure and Substrate Release in Group II Chaperonins 2 15
Reissmann, Stefanie Essential function of the built-in lid in the allosteric regulation of eukaryotic and archaeal chaperonins 3 30
Miller, Erik Chaperonin-mediated Folding of the VHL Tumor Suppressor Protein  4 15
Tam, Stephen The Chaperonin TRiC/CCT Controls Polyglutamine Aggregation and Toxicity Through Subunit-specific Interactions 5 15
Ayeung, William The first 17 amino acids of Huntingtin interacts with the chaperonin TRiC and are required for efficient aggregation. 6 5
King, Jonathan 7 5
Mills, Ishara Interactions of Mm-cpn with human lens crystallin substrates 8 15
  Break  
Jonasch, Eric (MDACC) TBA 9 30
Graef, Isabella (Stanford) TBA 10 30
Wells, Jim (UCSF) TBA 11 30
  Dinner at Stanford Faculty Club  
Day 2 Monday, May 28, 2007 (9:00 AM - 6:30 PM)
  Thomas Fogarty(http://www.fogartywinery.com/contact.html )  
Chair - Monday 9 - 12 noon Jonathan King  
Kortemme, Tanja 12 10
Mandell, Dan Engineering Adaptor Molecules for Novel Chaperonin-Substrate Interactions 13 15
Babor, Mariana Predicting and modulating protein conformational plasticity 14 15
Ludtke, Steven Macromolecular Dynamics using CryoEM 15 20
Chiu, Wah 16 10
Zhang, George CryoEM of Mm-cpn   17 15
Cong, Yao CryoEM of TRiC in nucleotide binding cycle 18 15
  Break  
Moerner, W.E. 19 10
Kim, So Yeon Two distinct mechanisms of VHL (von Hippel-Lindau) tumor suppressor folding occur with different chaperonins, TRiC and GroEL 20 15
Cui, Jian Probing TRiC Folding of Actin Using Single-Molecule Fluorescence 21 15
  Lunch along with group discussion   60
Chair: Monday 1 - 6:30 pm Paul Adams  
Report from discussion 60
Sali, Andrej 22 10
Korkin, Dmitry Specificity of interactions in protein assemblies: Application to TriC/CCT chaperonin 23 15
Foester, Friedrick Modeling for structure determination of mulitdomain proteins and complexes 24 15
Lasker, Keren Determining the configuration of macromolecular assembly components based on cryoEM density fitting and pairwise geometric complementarity 25 15
Adams, Paul 26 15
Pande, Vijay 27 10
England, Jeremy Modulation of the hydrophobic effect through confinement: a new model for chaperonin action 28 15
Lucent, Del Targets:  A strategy to develop chaperone inhibitors 29 15
  Break  
Levitt, Michael 30 10
Schroeder, Gunnar Conformational sampling under low resolution experimental restraints 31 15
Saha, Mitul Identifying Conserved Domains in Low-Resolution Volumetric Electron-Microscopy (EM) Maps 32 15
Minary, Peter Novel Sampling Tools and Coarse Grained Knowledge Based Potentials 33 15
Chopra, Gaurav Near-Native Protein Structure Refinement in Vacuum, Implicit and Explicit Solvent 34 15
David Gossard 35
Pintilie, Greg Visualizing the TRiC-Actin Complex using Molecular Dynamics  36 15
Gossard, Dave & King, Jonathan Education 37 20
Chiu, Wah Pathway to Medicine 38 20
  Dinner at Thomas Fogarty  
Day 3 Tuesday, May 29, 2007 (9:00 - 12:00 Noon) 
Clark Center, http://www.stanford.edu/hpcgi/map/index.pl?q=clark+center
Break up Groups